Search results for " HPV16"

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Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with H…

2011

Abstract Background There is increasing evidence for the role of High Risk (HR) Human PapillomaVirus (HPV) in the pathogenesis of Oral Squamous Cell Carcinoma (OSCC). The E6 and E7 oncogenes from HR HPVs are responsible for the deregulation of p53 and pRB proteins involved in cell cycle and apoptotic pathways. In cell lines experiments, the HPV E7 protein seems to be able to enhance Hypoxia Inducible Factor-1 alpha (HIF-1α) activity, normally involved in the response to hypoxia and able to enhance angiogenesis. Results We studied tumor specimens from 62 OSCC; a higher prevalence of tumors in TNM stage II and also in pT2 class between OSCC infected positive HPV16 DNA than non-infected ones w…

HPV16Cancer ResearchPathologymedicine.medical_specialtyHPVNecrosisAngiogenesisEpidemiologyAlpha (ethology)BiologyOral Squamous Cell Carcinomalcsh:RC254-282lcsh:Infectious and parasitic diseasesPathogenesisHypoxia-Inducible Factor 1-Alphachemistry.chemical_compoundmedicinelcsh:RC109-216E7Oral Squamous Cell Carcinoma Hif-1α HPV HPV16 E7virus diseasesHypoxia (medical)lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensfemale genital diseases and pregnancy complicationsstomatognathic diseasesInfectious DiseaseschemistryOncologyApoptosisCancer researchmedicine.symptomHif-1αDNAResearch ArticleInfectious agents and cancer
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